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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344478
Species: Homo sapiens
RGD Object: Gene
Symbol: HDAC8
Name: histone deacetylase 8
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HDAC8increases expressionEXP 6480464CTDbisphenol A results in increased expression of HDAC8 mRNAPMID:22576693
HDAC8increases methylationEXP 6480464CTDbisphenol A results in increased methylation of HDAC8 genePMID:31601247
HDAC8multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of HDAC8 mRNAPMID:28628672
HDAC8decreases expressionISOHdac8 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HDAC8 mRNAPMID:34585602
HDAC8increases expressionISOHdac8 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HDAC8 mRNAPMID:25181051
HDAC8increases methylationISOHdac8 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of HDAC8 genePMID:28505145
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