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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320123
Species: Mus musculus
RGD Object: Gene
Symbol: E2f3
Name: E2F transcription factor 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f3affects methylationEXP 6480464CTDbisphenol A affects the methylation of E2F3 promoterPMID:27334623
E2f3decreases expressionISOE2f3 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of E2F3 mRNAPMID:25181051
E2f3increases expressionISOE2F3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of E2F3 proteinPMID:21277958
E2f3multiple interactionsISOE2F3 (Homo sapiens)6480464CTD[bisphenol A co-treated with Quercetin metabolite] results in decreased expression of E2F3 mRNA; [naringenin co-treated with bisphenol A] results in increased expression of E2F3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F3 mRNAPMID:36235125 PMID:36982678
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