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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1320084
Species: Homo sapiens
RGD Object: Gene
Symbol: GUK1
Name: guanylate kinase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GUK1decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of GUK1 genePMID:31601247
GUK1decreases expressionISOGuk1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of GUK1 mRNAPMID:30816183 PMID:32528016
GUK1increases expressionISOGuk1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of GUK1 mRNAPMID:25181051 PMID:32145629 PMID:34947998
GUK1increases expressionISOGuk1 (Mus musculus)6480464CTDbisphenol A results in increased expression of GUK1 mRNAPMID:32156529 PMID:38074096
GUK1multiple interactionsISOGuk1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GUK1 mRNAPMID:36041667
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