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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316832
Species: Homo sapiens
RGD Object: Gene
Symbol: HDAC4
Name: histone deacetylase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HDAC4decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of HDAC4 genePMID:31601247
HDAC4increases expressionEXP 6480464CTDbisphenol A results in increased expression of HDAC4 mRNAPMID:32030086
HDAC4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of HDAC4 genePMID:31601247
HDAC4affects methylationISOHdac4 (Mus musculus)6480464CTDbisphenol A affects the methylation of HDAC4 promoterPMID:27334623
HDAC4decreases expressionISOHdac4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HDAC4 mRNAPMID:32926169
HDAC4increases methylationISOHdac4 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of HDAC4 genePMID:28505145
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