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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1316135
Species: Homo sapiens
RGD Object: Gene
Symbol: H2BC5
Name: H2B clustered histone 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2BC5decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of H2BC5 mRNAPMID:19371625 PMID:29275510
H2BC5multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of H2BC5 mRNAPMID:28628672
H2BC5decreases expressionISOHist1h2bd (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HIST1H2BD mRNAPMID:25181051
H2BC5increases expressionISOHist1h2bd (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of HIST1H2BD mRNAPMID:25181051 PMID:30816183 PMID:32528016
H2BC5increases methylationISOHist1h2bd (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of HIST1H2BD genePMID:28505145
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