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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313498
Species: Homo sapiens
RGD Object: Gene
Symbol: PPM1D
Name: protein phosphatase, Mg2+/Mn2+ dependent 1D
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPM1Ddecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PPM1D mRNAPMID:36982678
PPM1Dmultiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PPM1D mRNAPMID:28628672 PMID:36235125
PPM1Dincreases expressionISOPpm1d (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of PPM1D mRNAPMID:25181051 PMID:30816183 PMID:33296240 PMID:34947998
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