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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311894
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tpx2
Name: TPX2, microtubule nucleation factor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpx2increases expressionEXP 6480464CTDbisphenol A results in increased expression of TPX2 mRNAPMID:25181051 PMID:32145629
Tpx2increases methylationEXP 6480464CTDbisphenol A results in increased methylation of TPX2 genePMID:28505145
Tpx2affects expressionISOTPX2 (Homo sapiens)6480464CTDbisphenol A affects the expression of TPX2 mRNAPMID:30903817
Tpx2affects localizationISOTPX2 (Homo sapiens)6480464CTDbisphenol A affects the localization of TPX2 proteinPMID:30980863
Tpx2decreases expressionISOTPX2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of TPX2 mRNAPMID:29275510
Tpx2decreases expressionISOTpx2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of TPX2 mRNAPMID:17706920
Tpx2multiple interactionsISOTPX2 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPX2 mRNAPMID:28628672
Tpx2multiple interactionsISOTpx2 (Mus musculus)6480464CTDLHB protein affects the reaction [bisphenol A results in decreased expression of TPX2 mRNA]PMID:17706920
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