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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311364
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tmem218
Name: transmembrane protein 218
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tmem218decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TMEM218 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Tmem218multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of TMEM218 mRNA; [bisphenol A co-treated with Estradiol] results in decreased expression of TMEM218 mRNAPMID:26496021 PMID:36041667
Tmem218increases expressionISOTmem218 (Mus musculus)6480464CTDbisphenol A results in increased expression of TMEM218 mRNAPMID:32156529
Tmem218increases methylationISOTMEM218 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of TMEM218 genePMID:31601247
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