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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311014
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbx2
Name: T-box transcription factor 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbx2affects expressionEXP 6480464CTDbisphenol A affects the expression of TBX2 mRNAPMID:25181051
Tbx2affects methylationEXP 6480464CTDbisphenol A affects the methylation of TBX2 promoterPMID:27415467
Tbx2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of TBX2 mRNAPMID:34947998
Tbx2increases expressionEXP 6480464CTDbisphenol A results in increased expression of TBX2 mRNAPMID:30816183 PMID:32528016
Tbx2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TBX2 promoterPMID:23359474
Tbx2affects methylationISOTbx2 (Mus musculus)6480464CTDbisphenol A affects the methylation of TBX2 promoterPMID:27334623
Tbx2decreases expressionISOTbx2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of TBX2 mRNAPMID:25594700
Tbx2increases expressionISOTbx2 (Mus musculus)6480464CTDbisphenol A results in increased expression of TBX2 mRNAPMID:30951980 PMID:34585602
Tbx2multiple interactionsISOTBX2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of TBX2 genePMID:31601247
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