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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310780
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hoxb3
Name: homeo box B3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hoxb3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HOXB3 mRNAPMID:25181051
Hoxb3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of HOXB3 promoter; [bisphenol A co-treated with Estradiol] results in decreased expression of HOXB3 mRNAPMID:23359474 PMID:26496021
Hoxb3affects methylationISOHoxb3 (Mus musculus)6480464CTDbisphenol A affects the methylation of HOXB3 promoterPMID:27334623
Hoxb3decreases expressionISOHOXB3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of HOXB3 mRNAPMID:23146750
Hoxb3increases expressionISOHOXB3 (Homo sapiens)6480464CTDbisphenol A results in increased expression of HOXB3 mRNAPMID:31715268
Hoxb3increases expressionISOHoxb3 (Mus musculus)6480464CTDbisphenol A results in increased expression of HOXB3 mRNAPMID:30951980
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