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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310568
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp2
Name: poly (ADP-ribose) polymerase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PARP2 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Parp2increases expressionEXP 6480464CTDbisphenol A results in increased expression of PARP2 mRNAPMID:25181051
Parp2decreases expressionISOPARP2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of PARP2 mRNAPMID:29275510
Parp2increases expressionISOPARP2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of PARP2 mRNAPMID:33670352
Parp2increases methylationISOPARP2 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of PARP2 genePMID:31601247
Parp2multiple interactionsISOPARP2 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of PARP2 genePMID:31601247
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