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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irf4
Name: interferon regulatory factor 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irf4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of IRF4 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Irf4increases expressionEXP 6480464CTDbisphenol A results in increased expression of IRF4 mRNAPMID:34947998
Irf4affects methylationISOIrf4 (Mus musculus)6480464CTDbisphenol A affects the methylation of IRF4 promoterPMID:27334623
Irf4decreases expressionISOIrf4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of IRF4 mRNAPMID:38074096
Irf4decreases methylationISOIRF4 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of IRF4 genePMID:31601247
Irf4increases expressionISOIRF4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of IRF4 mRNAPMID:27685785
Irf4increases expressionISOIrf4 (Mus musculus)6480464CTDbisphenol A results in increased expression of IRF4 mRNAPMID:32156529
Irf4multiple interactionsISOIRF4 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of IRF4 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of IRF4 mRNAPMID:28628672 PMID:31601247
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