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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307927
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dennd1a
Name: DENN domain containing 1A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dennd1adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of DENND1A mRNAPMID:25181051
Dennd1aincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of DENND1A genePMID:28505145
Dennd1aaffects methylationISODENND1A (Homo sapiens)6480464CTDbisphenol A affects the methylation of DENND1A genePMID:31601247
Dennd1amultiple interactionsISODENND1A (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of DENND1A genePMID:31601247
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