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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307237
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arhgap22
Name: Rho GTPase activating protein 22
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arhgap22decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ARHGAP22 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Arhgap22increases expressionEXP 6480464CTDbisphenol A results in increased expression of ARHGAP22 mRNAPMID:25181051
Arhgap22decreases methylationISOARHGAP22 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of ARHGAP22 genePMID:31601247
Arhgap22increases expressionISOArhgap22 (Mus musculus)6480464CTDbisphenol A results in increased expression of ARHGAP22 mRNAPMID:30245210 PMID:32156529
Arhgap22multiple interactionsISOARHGAP22 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of ARHGAP22 gene; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ARHGAP22 mRNAPMID:28628672 PMID:31601247
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