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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306654
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bub3
Name: BUB3 mitotic checkpoint protein
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bub3increases expressionEXP 6480464CTDbisphenol A results in increased expression of BUB3 mRNAPMID:25181051 PMID:30816183 PMID:34947998
Bub3decreases expressionISOBUB3 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of BUB3 mRNA; bisphenol A results in decreased expression of BUB3 proteinPMID:29275510 PMID:37567409
Bub3decreases methylationISOBUB3 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of BUB3 genePMID:31601247
Bub3multiple interactionsISOBUB3 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BUB3 mRNAPMID:28628672
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