Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	1306035
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Yap1
Name:	Yes1 associated transcriptional regulator

Acc ID:	CHEBI:33216
Term:	bisphenol A
Definition:	A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID:	MESH:C006780

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Yap1	decreases expression	EXP		6480464	CTD	bisphenol A results in decreased expression of YAP1 mRNA	PMID:25181051 PMID:34947998
Yap1	increases methylation	EXP		6480464	CTD	bisphenol A results in increased methylation of YAP1 gene	PMID:28505145
Yap1	increases expression	ISO	YAP1 (Homo sapiens)	6480464	CTD	bisphenol A results in increased expression of YAP1 protein	PMID:37567409
Yap1	increases expression	ISO	Yap1 (Mus musculus)	6480464	CTD	bisphenol A results in increased expression of YAP1 mRNA	PMID:26063408
Yap1	increases phosphorylation	ISO	Yap1 (Mus musculus)	6480464	CTD	bisphenol A results in increased phosphorylation of YAP1 protein	PMID:35219798
Yap1	multiple interactions	ISO	Yap1 (Mus musculus)	6480464	CTD	Imatinib Mesylate inhibits the reaction [bisphenol A results in increased phosphorylation of YAP1 protein]	PMID:35219798

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