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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306012
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf14
Name: KLF transcription factor 14
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf14decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of KLF14 mRNAPMID:25181051
Klf14increases methylationEXP 6480464CTDbisphenol A results in increased methylation of KLF14 genePMID:28505145
Klf14increases expressionISOKlf14 (Mus musculus)6480464CTDbisphenol A results in increased expression of KLF14 mRNAPMID:34585602
Klf14multiple interactionsISOKlf14 (Mus musculus)6480464CTD[bisphenol A results in decreased methylation of KLF14 exon] which results in decreased abundance of 5-hydroxymethylcytosinePMID:30044229
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