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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp8
Name: LDL receptor related protein 8
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp8affects expressionEXP 6480464CTDbisphenol A affects the expression of LRP8 mRNAPMID:30816183 PMID:34947998
Lrp8decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LRP8 mRNAPMID:25181051
Lrp8decreases methylationISOLRP8 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of LRP8 genePMID:31601247
Lrp8decreases methylationISOLrp8 (Mus musculus)6480464CTDbisphenol A results in decreased methylation of LRP8 promoterPMID:27312807
Lrp8multiple interactionsISOLRP8 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of LRP8 mRNAPMID:28628672
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