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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plk4
Name: polo-like kinase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of PLK4 mRNA

PMID:26982218, PMID:30816183
Plk4increases expressionEXP 6480464CTDbisphenol A results in increased expression of PLK4 mRNA

PMID:25181051
Plk4decreases expressionISORGD:13133926480464CTDbisphenol A results in decreased expression of PLK4 mRNA

PMID:29275510
Plk4increases expressionISORGD:13133926480464CTDbisphenol A results in increased expression of PLK4 mRNA

PMID:16474171
Plk4increases expressionISORGD:13133936480464CTDbisphenol A results in increased expression of PLK4 mRNA

PMID:26063408
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.