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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305322
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map4k4decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MAP4K4 mRNAPMID:32145629
Map4k4increases expressionEXP 6480464CTDbisphenol A results in increased expression of MAP4K4 mRNAPMID:25181051 PMID:30816183 PMID:34947998
Map4k4increases methylationEXP 6480464CTDbisphenol A results in increased methylation of MAP4K4 genePMID:28505145
Map4k4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of MAP4K4 mRNAPMID:36041667
Map4k4affects expressionISOMAP4K4 (Homo sapiens)6480464CTDbisphenol A affects the expression of MAP4K4 mRNAPMID:30903817
Map4k4affects methylationISOMAP4K4 (Homo sapiens)6480464CTDbisphenol A affects the methylation of MAP4K4 genePMID:31601247
Map4k4decreases expressionISOMAP4K4 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MAP4K4 proteinPMID:33376534
Map4k4decreases expressionISOMap4k4 (Mus musculus)6480464CTDbisphenol A results in decreased expression of MAP4K4 mRNAPMID:38074096
Map4k4increases expressionISOMAP4K4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MAP4K4 proteinPMID:34186270
Map4k4multiple interactionsISOMAP4K4 (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] affects the methylation of MAP4K4 genePMID:31601247
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