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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303135
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npc1l1decreases expressionISONpc1l1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of NPC1L1 mRNAPMID:32156529
Npc1l1increases expressionISONPC1L1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of NPC1L1 mRNA; bisphenol A results in increased expression of NPC1L1 proteinPMID:28057006
Npc1l1increases expressionISONpc1l1 (Mus musculus)6480464CTDbisphenol A results in increased expression of NPC1L1 mRNA; bisphenol A results in increased expression of NPC1L1 proteinPMID:34585602 PMID:37701206
Npc1l1multiple interactionsISONPC1L1 (Homo sapiens)6480464CTDSREBF2 promotes the reaction [bisphenol A results in increased expression of NPC1L1 mRNA]PMID:28057006
Npc1l1multiple interactionsISONpc1l1 (Mus musculus)6480464CTD[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of NPC1L1 mRNA; Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein]PMID:30722647 PMID:37701206
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