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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11452
Species: Mus musculus
RGD Object: Gene
Symbol: Trh
Name: thyrotropin releasing hormone
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trhincreases expressionEXP 6480464CTDbisphenol A results in increased expression of TRH mRNA

PMID:30951980
Trhdecreases expressionISORGD:39036480464CTDbisphenol A results in decreased expression of TRH mRNA

PMID:25181051
Trhincreases expressionISORGD:39036480464CTDbisphenol A results in increased expression of TRH mRNA

PMID:30816183
Trhincreases methylationISORGD:39036480464CTDbisphenol A results in increased methylation of TRH gene

PMID:28505145
Trhmultiple interactionsISORGD:39036480464CTDbisphenol A inhibits the reaction [TRH protein results in increased secretion of PRL protein], bisphenol A inhibits the reaction [TRH protein results in increased secretion of TSHB protein]

PMID:29305326
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.