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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11213
Species: Mus musculus
RGD Object: Gene
Symbol: Rab4a
Name: RAB4A, member RAS oncogene family
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab4aincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of RAB4A promoterPMID:27312807
Rab4adecreases expressionISORAB4A (Homo sapiens)6480464CTDbisphenol A results in decreased expression of RAB4A mRNAPMID:22576693 PMID:29275510
Rab4adecreases expressionISORab4a (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of RAB4A mRNAPMID:34947998
Rab4aincreases methylationISORAB4A (Homo sapiens)6480464CTDbisphenol A results in increased methylation of RAB4A genePMID:22576693 PMID:31601247
Rab4amultiple interactionsISORab4a (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RAB4A mRNA; [bisphenol A co-treated with Estradiol] results in decreased expression of RAB4A mRNA; [bisphenol A co-treated with Genistein] results in increased methylation of RAB4A genePMID:26496021 PMID:28505145 PMID:36041667
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