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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityEXP 6480464CTDbisphenol A affects the activity of ESR2 protein

PMID:17222059
affects expressionEXP 6480464CTDbisphenol A affects the expression of ESR2, bisphenol A affects the expression of ESR2 mRNA, bisphenol A affects the expression of ESR2 protein

PMID:23716699, PMID:23719926, PMID:28476547
affects localizationEXP 6480464CTDbisphenol A affects the localization of ESR2 protein

PMID:20950447
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of ESR2 mRNA, bisphenol A results in decreased expression of ESR2 protein

PMID:12505546, PMID:20206181, PMID:21182934, PMID:25112706, PMID:29161229
increases activityEXP 6480464CTDbisphenol A results in increased activity of ESR2 protein

PMID:31551929
increases expressionEXP 6480464CTDbisphenol A results in increased expression of ESR2 mRNA, bisphenol A results in increased expression of ESR2 protein

PMID:14664715, PMID:14967926, PMID:17222491, PMID:20088799, PMID:22131059, PMID:26063408, PMID:26863571, PMID:26911702, PMID:27634370, PMID:30196065, PMID:31201698, PMID:31463084, PMID:31551929
increases methylationEXP 6480464CTDbisphenol A results in increased methylation of ESR2 promoter

PMID:31463084
increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of ESR2 protein

PMID:31551929
multiple interactionsEXP 6480464CTD[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of ESR2 protein, bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], bisphenol A inhibits the reaction [Ovalbumin results in decreased expression of ESR2 mRNA], bisphenol A inhibits the reaction [Streptozocin results in decreased expression of ESR2 mRNA], ESR2 promotes the reaction [bisphenol A results in increased secretion of INS1 protein], ESR2 protein affects the reaction [bisphenol A affects the expression of CACNA1I mRNA], ESR2 protein affects the reaction [bisphenol A results in decreased expression of KCNB2 mRNA], ESR2 protein affects the reaction [bisphenol A results in decreased expression of KCNIP1 mRNA], ESR2 protein affects the reaction [bisphenol A results in decreased expression of KCNMA1 mRNA], ESR2 protein affects the reaction [bisphenol A results in decreased expression of SCN9A mRNA], ESR2 protein affects the reaction [bisphenol A results in increased expression of CACNA1G mRNA], ESR2 protein affects the reaction [bisphenol A results in increased expression of CACNA1H mRNA], ESR2 protein alternative form inhibits the reaction [bisphenol A results in increased expression of ESR2 protein], Fulvestrant inhibits the reaction [[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with bisphenol A] results in increased activity of ESR2 protein], NCOA1 protein promotes the reaction [bisphenol A results in increased expression of ESR2 protein], NCOA2 protein promotes the reaction [bisphenol A results in increased expression of ESR2 protein]

PMID:22347437, PMID:24781736, PMID:25958630, PMID:26944108, PMID:27634370, PMID:28476547, PMID:29737898, PMID:31250031
affects bindingISORGD:25826480464CTDbisphenol A binds to ESR2 protein

PMID:15458795, PMID:19913605
affects bindingISORGD:692136480464CTDbisphenol A analog binds to ESR2 protein, bisphenol A binds to ESR2 protein

PMID:10964929, PMID:11518614, PMID:12161000, PMID:12224631, PMID:14691209, PMID:14723943, PMID:15596252, PMID:17713618, PMID:19913605, PMID:20836126, PMID:23768907, PMID:25130739, PMID:29499249
affects expressionISORGD:25826480464CTDbisphenol A affects the expression of ESR2, bisphenol A affects the expression of ESR2 mRNA, bisphenol A metabolite affects the expression of ESR2 mRNA

PMID:20435109, PMID:21112483, PMID:23457122, PMID:24352099
affects expressionISORGD:692136480464CTDbisphenol A affects the expression of ESR2

PMID:26021997
affects localizationISORGD:25826480464CTDbisphenol A affects the localization of ESR2 protein

PMID:19479021
decreases expressionISORGD:25826480464CTDbisphenol A results in decreased expression of ESR2 mRNA, bisphenol A results in decreased expression of ESR2 protein

PMID:15548368, PMID:19837096, PMID:20821433, PMID:22101008, PMID:22285353, PMID:22957036, PMID:24752507, PMID:24884420, PMID:25181051, PMID:26788107, PMID:27338438, PMID:30312744
decreases expressionISORGD:692136480464CTDbisphenol A results in decreased expression of ESR2 mRNA, bisphenol A results in decreased expression of ESR2 protein

PMID:18007998, PMID:23222814
increases activityISORGD:25826480464CTDbisphenol A results in increased activity of ESR2 protein

PMID:22166976
increases activityISORGD:692136480464CTDbisphenol A analog results in increased activity of ESR2 protein, bisphenol A results in increased activity of ESR2 protein

PMID:12402979, PMID:14754635, PMID:16756374, PMID:19161236, PMID:23056236, PMID:23714657, PMID:24284790, PMID:26139245, PMID:27522653, PMID:28701262, PMID:30582956, PMID:30951782
increases expressionISORGD:25826480464CTDbisphenol A results in increased expression of ESR2, bisphenol A results in increased expression of ESR2 mRNA, bisphenol A results in increased expression of ESR2 protein

PMID:11108262, PMID:12810577, PMID:14605012, PMID:20692330, PMID:25575453, PMID:26788107, PMID:27571134, PMID:27830003, PMID:28067316, PMID:28641706, PMID:28928807, PMID:28959593, PMID:29097150
increases expressionISORGD:692136480464CTDbisphenol A results in increased expression of ESR2 mRNA, bisphenol A results in increased expression of ESR2 protein

PMID:12737316, PMID:14664715, PMID:21831745, PMID:22121209, PMID:24231368, PMID:25143472, PMID:25534675, PMID:28882636, PMID:31278978
increases methylationISORGD:25826480464CTDbisphenol A results in increased methylation of ESR2 promoter

PMID:21827818
increases response to substanceISORGD:25826480464CTDESR2 protein results in increased susceptibility to bisphenol A

PMID:24140712, PMID:24569941
multiple interactionsISORGD:25826480464CTD[bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA, [bisphenol A co-treated with Genistein] results in decreased expression of ESR2 protein, [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene] results in increased expression of ESR2 mRNA, [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA, [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA], [Gonadotropins, Equine co-treated with bisphenol A] results in increased expression of ESR2 protein, bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein alternative form], bisphenol A promotes the reaction [ESR2 protein binds to CAV1 protein], ESR1 protein results in decreased susceptibility to [bisphenol A co-treated with ESR2 protein]

PMID:22166976, PMID:24884420, PMID:27338438, PMID:28067316, PMID:28648634, PMID:9492041
multiple interactionsISORGD:692136480464CTD[bisphenol A co-treated with ESR2 protein] results in increased expression of LTF mRNA, [bisphenol A co-treated with methylparaben co-treated with perfluorooctanoic acid] results in decreased expression of ESR2 protein, AR protein mutant form affects the reaction [bisphenol A results in decreased expression of ESR2 mRNA], bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], bisphenol A analog binds to and results in decreased activity of ESR2 protein, bisphenol A analog binds to and results in increased activity of ESR2 protein, bisphenol A analog inhibits the reaction [Estradiol binds to and results in increased activity of ESR2 protein], bisphenol A analog inhibits the reaction [Estradiol results in increased activity of ESR2 protein], bisphenol A binds to and results in increased activity of ESR2 protein, bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 protein], bisphenol A inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein], bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein], bisphenol A promotes the reaction [ESR2 protein binds to EZH2 promoter], bisphenol A promotes the reaction [ESR2 protein binds to HOTAIR promoter], bisphenol A promotes the reaction [ESR2 protein binds to NCOA1 protein], bisphenol A promotes the reaction [ESR2 protein binds to NCOA2 protein], bisphenol A results in increased activity of [ESR1 protein co-treated with ESR2 protein], ESR2 protein promotes the reaction [bisphenol A results in increased expression of HOTAIR mRNA], Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], Fulvestrant inhibits the reaction [bisphenol A results in increased expression of ESR2 mRNA], Gefitinib inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], Sodium Hypochlorite inhibits the reaction [bisphenol A binds to ESR2 protein]

PMID:10964929, PMID:11258963, PMID:11335189, PMID:12765243, PMID:14709801, PMID:14723943, PMID:18007998, PMID:20427257, PMID:20836126, PMID:21561829, PMID:21622942, PMID:21783566, PMID:22507746, PMID:22927406, PMID:23857583, PMID:24533973, PMID:25088689, PMID:27633901, PMID:28882636, PMID:29383186, PMID:29846718, PMID:30582956, PMID:31195007, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.