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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:33083
Term: fluoranthene
Definition: An ortho- and peri-fused polycyclic arene consisting of a naphthalene and benzene unit connected by a five-membered ring.
Chemical ID: MESH:C007738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDfluoranthene results in increased expression of NOS3 mRNA; fluoranthene results in increased expression of NOS3 proteinPMID:15183461
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [fluoranthene results in increased expression of NOS3 mRNA]; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; Proadifen inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]PMID:15183461
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