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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:3305
Term: Calcimycin
Definition: An aminobenzoic acid that has formula C29H37N3O6.
Chemical ID: MESH:D000001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCalcimycin results in increased expression of DDIT3 protein

PMID:11145585
increases activityISORGD:691656480464CTDCalcimycin results in increased activity of DDIT3 protein

PMID:19139269
increases expressionISORGD:691656480464CTDCalcimycin results in increased expression of DDIT3 mRNA, Calcimycin results in increased expression of DDIT3 protein

PMID:11360202, PMID:19428936, PMID:27064126
multiple interactionsISORGD:691656480464CTDparthenolide promotes the reaction [Calcimycin results in increased expression of DDIT3 mRNA], Quercetin inhibits the reaction [Calcimycin results in increased expression of DDIT3 mRNA], RELA protein inhibits the reaction [Calcimycin results in increased expression of DDIT3 mRNA]

PMID:11360202, PMID:19428936
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.