GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alox5 | increases activity | ISO | ALOX5 (Homo sapiens) | 6480464 | CTD | Calcimycin results in increased activity of ALOX5 protein | PMID:11698504 PMID:18475477 | Alox5 | increases expression | ISO | Alox5 (Rattus norvegicus) | 6480464 | CTD | Calcimycin results in increased expression of ALOX5 mRNA; Calcimycin results in increased expression of ALOX5 protein | PMID:18083043 | Alox5 | multiple interactions | ISO | Alox5 (Rattus norvegicus) | 6480464 | CTD | [[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4; [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; Calcimycin results in increased activity of and results in increased localization of ALOX5 protein; Calcimycin results in increased localization of and results in increased activity of ALOX5 protein; CCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 mRNA]; CCL5 protein promotes the reaction [Calcimycin results in increased expression of ALOX5 protein]; Dexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] | PMID:11529688 PMID:18083043 PMID:18475545 PMID:7665580 PMID:9445378 | Alox5 | multiple interactions | ISO | ALOX5 (Homo sapiens) | 6480464 | CTD | 1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]]; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]; [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]; bisindolylmaleimide I inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; bolinaquinone inhibits the reaction [Calcimycin results in increased activity of ALOX5 protein]; Calcimycin results in increased activity of and results in increased localization of ALOX5 protein; Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein; Propranolol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]; SB 203580 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; tert-Butyl Alcohol inhibits the reaction [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein]; U 0126 inhibits the reaction [Calcimycin results in increased phosphorylation of and results in increased activity of ALOX5 protein] | PMID:10779545 PMID:11698504 PMID:12604694 PMID:18218859 PMID:8387780 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |