Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732184
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT1affects response to substanceEXP 6480464CTDSTAT1 protein affects the susceptibility to chromium hexavalent ionPMID:19403854
STAT1increases activityEXP 6480464CTD[chromium hexavalent ion results in increased activity of FYN protein] which results in increased activity of STAT1 proteinPMID:19994902
STAT1multiple interactionsEXP 6480464CTDchromium hexavalent ion results in increased phosphorylation of and affects the localization of STAT1 protein; FYN protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of STAT1 protein]; STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]]; STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]]; STAT1 protein affects the reaction [chromium hexavalent ion results in decreased expression of VEGFA mRNA]; STAT1 protein affects the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]PMID:17078813 PMID:19403854 PMID:19994902
STAT1affects expressionISOStat1 (Mus musculus)6480464CTDchromium hexavalent ion affects the expression of STAT1 mRNAPMID:28472532
STAT1multiple interactionsISOStat1 (Mus musculus)6480464CTDchromium hexavalent ion results in increased phosphorylation of and results in increased activity of STAT1 proteinPMID:19994902
Go Back to source page   Continue to Ontology report