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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730872
Species: Homo sapiens
RGD Object: Gene
Symbol: SOD2
Name: superoxide dismutase 2
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOD2decreases response to substanceEXP 6480464CTDSOD2 protein results in decreased susceptibility to chromium hexavalent ionPMID:21742780
SOD2increases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of SOD2 proteinPMID:20186739
SOD2decreases expressionISOSod2 (Mus musculus)6480464CTDchromium hexavalent ion results in decreased expression of SOD2 proteinPMID:22552367
SOD2decreases expressionISOSod2 (Rattus norvegicus)6480464CTDchromium hexavalent ion results in decreased expression of SOD2 mRNA; chromium hexavalent ion results in decreased expression of SOD2 proteinPMID:28077780 PMID:35024197
SOD2increases expressionISOSod2 (Rattus norvegicus)6480464CTDchromium hexavalent ion results in increased expression of SOD2 proteinPMID:24530425 PMID:28077780
SOD2multiple interactionsISOSod2 (Rattus norvegicus)6480464CTDResveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of SOD2 mRNA]; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of SOD2 protein]PMID:35024197
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