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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionISOSqstm1 (Mus musculus)6480464CTDchromium hexavalent ion results in decreased expression of SQSTM1 proteinPMID:36739042
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDchromium hexavalent ion results in increased expression of and results in increased phosphorylation of SQSTM1 proteinPMID:30715550
Sqstm1multiple interactionsISOSqstm1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of SQSTM1 protein]; BNIP3 protein affects the reaction [chromium hexavalent ion results in decreased expression of SQSTM1 protein]; HIF1A protein affects the reaction [chromium hexavalent ion results in decreased expression of SQSTM1 protein]; YTHDF2 protein inhibits the reaction [chromium hexavalent ion results in decreased expression of SQSTM1 protein]PMID:36739042
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