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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of GCLC proteinPMID:18306314
Gclcmultiple interactionsISOGclc (Mus musculus)6480464CTD[Arsenates co-treated with chromium hexavalent ion] results in increased expression of GCLC mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GCLC mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] results in increased expression of GCLC proteinPMID:19895865 PMID:25820237
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