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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557923
Species: Mus musculus
RGD Object: Gene
Symbol: Atr
Name: ataxia telangiectasia and Rad3 related
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDchromium hexavalent ion affects the expression of ATR mRNA

PMID:28472532
multiple interactionsEXP 6480464CTDATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AX protein], ATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AX protein]

PMID:25288669
increases activityISORGD:13140476480464CTDchromium hexavalent ion results in increased activity of ATR protein

PMID:16876463
multiple interactionsISORGD:13140476480464CTDATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AX protein], ATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AX protein], chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein], RAD17 protein affects the reaction [chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]]

PMID:16876463, PMID:25288669
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.