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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346221
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR143
Name: microRNA 143
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR143affects response to substanceEXP 6480464CTDMIR143 affects the susceptibility to chromium hexavalent ionPMID:23748240
MIR143decreases expressionEXP 6480464CTDchromium hexavalent ion results in decreased expression of MIR143 mRNAPMID:23748240 PMID:31152816
MIR143multiple interactionsEXP 6480464CTDMIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of CXCL8 mRNA]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A protein]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IGF1R protein]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of IRS1 protein]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased localization of RELA protein]PMID:23748240
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