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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345686
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8increases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of CXCL8 mRNAPMID:23748240 PMID:27793765
CXCL8increases secretionEXP 6480464CTDchromium hexavalent ion results in increased secretion of CXCL8 proteinPMID:25448439
CXCL8multiple interactionsEXP 6480464CTDLuteolin inhibits the reaction [chromium hexavalent ion results in increased secretion of CXCL8 protein]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased expression of CXCL8 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [chromium hexavalent ion results in increased expression of CXCL8 mRNA]; U 0126 inhibits the reaction [chromium hexavalent ion results in increased expression of CXCL8 mRNA]PMID:23748240 PMID:25448439
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