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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycaffects expressionEXP 6480464CTDchromium hexavalent ion affects the expression of MYC mRNAPMID:28472532
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDchromium hexavalent ion results in increased expression of MYC mRNA; chromium hexavalent ion results in increased expression of MYC proteinPMID:19616015 PMID:27323401 PMID:32525551
Mycincreases response to substanceISOMYC (Homo sapiens)6480464CTDMYC results in increased susceptibility to chromium hexavalent ionPMID:31504995
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[chromium hexavalent ion results in decreased expression of MIR494] which results in increased expression of MYC mRNA; chromium hexavalent ion promotes the reaction [[CTNNB1 protein co-treated with TCF4 protein] binds to MYC promoter]PMID:27323401 PMID:31504995
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