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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects expressionEXP 6480464CTDchromium hexavalent ion affects the expression of JUN mRNAPMID:28472532
Junincreases expressionEXP 6480464CTDchromium hexavalent ion results in increased expression of JUN proteinPMID:19654923
Junincreases phosphorylationEXP 6480464CTDchromium hexavalent ion results in increased phosphorylation of JUN proteinPMID:19654923 PMID:22472290
Junmultiple interactionsEXP 6480464CTD[chromium hexavalent ion promotes the reaction [JUN protein binds to PTGS2 promoter]] which results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; chromium hexavalent ion promotes the reaction [JUN protein binds to PTGS2 promoter]; IKBKB protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; JUN protein mutant form inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of NFKBIA protein]; MAP2K4 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]PMID:19654923 PMID:22472290
Jundecreases expressionISOJun (Rattus norvegicus)6480464CTDchromium hexavalent ion results in decreased expression of JUN proteinPMID:32679048
Junincreases expressionISOJUN (Homo sapiens)6480464CTDchromium hexavalent ion results in increased expression of JUN mRNAPMID:27793765
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