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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDchromium hexavalent ion results in decreased expression of NQO1 mRNAPMID:16517059
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDchromium hexavalent ion results in decreased expression of NQO1 mRNA; chromium hexavalent ion results in decreased expression of NQO1 proteinPMID:35024197
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDchromium hexavalent ion results in decreased expression of NQO1 mRNAPMID:30690063
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDchromium hexavalent ion results in increased expression of NQO1 mRNAPMID:30690063
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of NQO1 mRNA; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of NQO1 protein; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of NQO1 mRNA]; Resveratrol inhibits the reaction [chromium hexavalent ion results in decreased expression of NQO1 protein]PMID:35024197 PMID:36849043
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