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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases activityEXP 6480464CTDHexachlorocyclohexane results in increased activity of CYP2E1 proteinPMID:12842176 PMID:14631868
Cyp2e1increases expressionEXP 6480464CTDHexachlorocyclohexane results in increased expression of CYP2E1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2E1 proteinPMID:12842176 PMID:14631868 PMID:17919674 PMID:17984293 PMID:23927878 PMID:25572523
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDHexachlorocyclohexane results in decreased expression of CYP2E1 mRNAPMID:20035023
Cyp2e1decreases response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in decreased susceptibility to HexachlorocyclohexanePMID:21458603
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