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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDHexachlorocyclohexane results in decreased expression of BAX proteinPMID:19041923
Baxdecreases expressionISOBAX (Homo sapiens)6480464CTDHexachlorocyclohexane results in decreased expression of BAX proteinPMID:18174961
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDHexachlorocyclohexane results in increased expression of BAX mRNA; Hexachlorocyclohexane results in increased expression of BAX proteinPMID:14688026
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDEstradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]PMID:18174961
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