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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2100
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alplincreases activityEXP 6480464CTDHexachlorocyclohexane results in increased activity of ALPL proteinPMID:11180283
Alplincreases expressionEXP 6480464CTDHexachlorocyclohexane results in increased expression of ALPL proteinPMID:11180283
Alplmultiple interactionsEXP 6480464CTD[Hexachlorocyclohexane co-treated with isoproturon] results in decreased activity of ALPL protein; [Hexachlorocyclohexane co-treated with isoproturon] results in increased expression of ALPL proteinPMID:11180283
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