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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDHexachlorocyclohexane results in decreased expression of ESR1 proteinPMID:21278053
Esr1multiple interactionsEXP 6480464CTDHexachlorocyclohexane binds to and results in increased activity of ESR1 proteinPMID:20209442
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDHexachlorocyclohexane binds to ESR1 proteinPMID:14579009 PMID:15253041
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDHexachlorocyclohexane results in increased activity of ESR1 proteinPMID:26022396 PMID:26139245
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]PMID:14579009 PMID:16329587 PMID:21295777
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