Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:32816
Term: pyruvic acid
Definition: A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Chemical ID: MESH:D019289
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTDPyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]; SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]]PMID:21933665
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A proteinPMID:19071085
Go Back to source page   Continue to Ontology report