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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:32692
Term: 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one
Definition: A nitrosamine that has formula C10H13N3O2.
Chemical ID: MESH:C016583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:7321846480464CTD4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein

PMID:16582591
increases expressionISORGD:7321846480464CTD4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA

PMID:16582591, PMID:16835749
multiple interactionsISORGD:7321846480464CTDBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein], Bungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of STAT1 mRNA], Mecamylamine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of STAT1 protein]

PMID:16582591, PMID:16835749
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.