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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733440
Species: Homo sapiens
RGD Object: Gene
Symbol: BECN1
Name: beclin 1
Acc ID: CHEBI:3259
Term: CCCP
Definition: A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Chemical ID: MESH:D002258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BECN1multiple interactionsEXP 6480464CTDBECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]PMID:24879156
BECN1multiple interactionsISOBecn1 (Rattus norvegicus)6480464CTDBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]PMID:24879156
BECN1multiple interactionsISOBecn1 (Mus musculus)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]PMID:24879156
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