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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:3259
Term: CCCP
Definition: A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Chemical ID: MESH:D002258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3increases expressionEXP 6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified formPMID:29241732
CASP3multiple interactionsEXP 6480464CTDDNM1L protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]; PGAM5 protein promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of CASP3 protein modified form]PMID:29241732
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [Testosterone results in increased cleavage of CASP3 protein]PMID:24658017
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