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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61797
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Acc ID: CHEBI:3259
Term: CCCP
Definition: A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Chemical ID: MESH:D002258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prknaffects localizationEXP 6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN proteinPMID:24879156
Prknincreases phosphorylationEXP 6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN proteinPMID:24879156
Prknmultiple interactionsEXP 6480464CTDBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]PMID:24879156
Prknaffects expressionISOPRKN (Homo sapiens)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative formPMID:28688199
Prknaffects localizationISOPrkn (Mus musculus)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN proteinPMID:22872702
Prknaffects localizationISOPRKN (Homo sapiens)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN proteinPMID:22872702 PMID:26070385 PMID:28673964
Prkndecreases expressionISOPRKN (Homo sapiens)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of PRKN proteinPMID:28688199
Prkndecreases response to substanceISOPrkn (Mus musculus)6480464CTDPRKN protein results in decreased susceptibility to Carbonyl Cyanide m-Chlorophenyl HydrazonePMID:16517603
Prknincreases phosphorylationISOPrkn (Mus musculus)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN proteinPMID:29660402
Prknincreases response to substanceISOPrkn (Mus musculus)6480464CTDPRKN gene mutant form results in increased susceptibility to Carbonyl Cyanide m-Chlorophenyl HydrazonePMID:16517603
Prknmultiple interactionsISOPrkn (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Acetylcysteine inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; PARK7 gene mutant form promotes the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]PMID:22872702 PMID:24879156
Prknmultiple interactionsISOPRKN (Homo sapiens)6480464CTD[Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein; BECN1 protein inhibits the reaction [BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [AMBRA1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [BECN1 protein binds to PRKN protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [PIK3C3 protein binds to PRKN protein]; Tretinoin affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form]PMID:24879156 PMID:28673964 PMID:28688199
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