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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10235
Species: Mus musculus
RGD Object: Gene
Symbol: Bdnf
Name: brain derived neurotrophic factor
Acc ID: CHEBI:32588
Term: potassium chloride
Definition: A metal chloride salt with a K(+) counterion.
Chemical ID: MESH:D011189
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bdnfdecreases methylationEXP 6480464CTDPotassium Chloride results in decreased methylation of BDNF promoterPMID:14593183
Bdnfincreases expressionEXP 6480464CTDPotassium Chloride results in increased expression of BDNF mRNAPMID:14593183
Bdnfmultiple interactionsEXP 6480464CTDBDNF promoter modified form affects the reaction [Potassium Chloride results in increased expression of BDNF mRNA]; Potassium Chloride inhibits the reaction [HDAC1 protein binds to BDNF promoter]; Potassium Chloride inhibits the reaction [MECP2 protein binds to BDNF promoter]; Potassium Chloride inhibits the reaction [SIN3A protein binds to BDNF promoter]; Potassium Chloride promotes the reaction [CREB1 protein binds to BDNF promoter]PMID:14593183
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