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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal

PMID:21967605
increases oxidationISORGD:692206480464CTDALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal

PMID:22339434
multiple interactionsISORGD:692206480464CTD4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein, ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]

PMID:22339434, PMID:25263579
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.