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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349200
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTA1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTA1decreases response to substanceEXP 6480464CTDGSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenalPMID:15829614
GSTA1affects metabolic processingISOGsta1 (Rattus norvegicus)6480464CTDGSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analogPMID:11256969
GSTA1increases expressionISOGsta1 (Rattus norvegicus)6480464CTD4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNAPMID:9799558
GSTA1multiple interactionsISOGsta1 (Rattus norvegicus)6480464CTD[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analogPMID:11256969
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