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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309970
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta4
Name: glutathione S-transferase alpha 4
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta4affects metabolic processingEXP 6480464CTDGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analogPMID:11256969 PMID:11488593 PMID:12600725 PMID:2619714 PMID:7878679
Gsta4increases expressionEXP 6480464CTD4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 proteinPMID:9799558
Gsta4affects metabolic processingISOGSTA4 (Homo sapiens)6480464CTDGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenalPMID:10514034 PMID:11162605 PMID:11302754 PMID:11488593 PMID:16005854 PMID:8142470 PMID:8203886 PMID:9461507
Gsta4multiple interactionsISOGSTA4 (Homo sapiens)6480464CTDGSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenalPMID:15829614
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